WebbSlide 1 Modeling Tumor Heterogeneity Peter M uller and Yanxun Xu, UT Austin Juhee Lee, UCSC, Yuan Ji, U Chicago & NorthShore, K. Gulukota, NorthShore Health System Webb13 dec. 2024 · We recently identified a subgroup of TNBC with loss of the tumor suppressor PTEN and five specific microRNAs that exhibits exceedingly poor clinical …
Clonal substructure of three triple-negative breast tumors Clonal...
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TNBC patients with the BL1 or MSL subtype have a higher rate of pCR, while the TNBC patients with the LAR and BL2 subtypes are not sensitive to the combination regimen. The pCR rate of patients with the BL2 subtype was 0%. Cyclophosphamide Cyclophosphamide does not have antitumor activity in vitro. Visa mer Nielsen et al. performed DNA microarray analysis on a large number of BLBC samples and found that approximately 60% of BLBC samples … Visa mer AR is expressed in both normal breast tissues and breast cancer tissues, but the levels are significantly different in different breast cancer tissues. AR expression is positive in approximately 10–15% of TNBC patients [53]. The LAR … Visa mer PARP is a class of DNA repair enzymes. Its major function is to maintain genome stability, repair DNA, and participate in cell cycle progression and apoptosis [45]. PARP-1 is one of the … Visa mer TNBC cells, being negative for ER, PR, and HER2 expression, are generally believed to not have intracellular estrogen signal transduction. They are insensitive to endocrine therapy and … Visa mer WebbThe role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells WT1 is located on short band 1 region 3 of human … Webb30 jan. 2024 · The NB2 devices contain Multicast transmission mode, which the NB1 device does not have. Enhanced NB2 mobility. NB2 devices provide better mobility – … line arrow svg