WebJun 26, 2024 · MIT engineers have developed calcium indicators, or sensors, that accumulate only in the body of a neuron. This makes the resulting measurement of an … WebMar 21, 2024 · GeneCards Summary for MAGI2-AS3 Gene. MAGI2-AS3 (MAGI2 Antisense RNA 3) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated …
UniProt
WebHere, we show that MAGI2 forms a complex with the Rap1 guanine nucleotide exchange factor, RapGEF2, and that this complex is lost when expressing MAGI2 CNS variants. Co-expression of RapGEF2 with wild-type MAGI2, but not MAGI2 CNS variants, enhanced activation of the small GTPase Rap1, a central signaling node in podocytes. WebPlays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation ( By similarity ). Involved in the regulation of synaptic function in excitatory hippocampal synapses. ferhat sonia
MO064: Expression Studies on Magi2 in Different FSGS Models
WebMembrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2) is a gene that encodes a protein that interacts with atrophin-1. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as skin cancer, stomach cancer, and colon cancer. WebMay 5, 2012 · Neuron transfection and immunocytochemistry. Dissociated hippocampal neuron culture was prepared from E18 embryos of either sex as described previously (Lee et al., ... et al. Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11. Am J Hum Genet. 2008; 83:106–111. [PMC free article] … WebMay 13, 2024 · neuron projection guidance GO:0007411 axon guidance GO:1990138 neuron projection extension GO:0048675 axon extension GO:0099003 vesicle-mediated transport in synapse GO:0097479 synaptic vesicle localization GO:0016049 cell growth GO:1904062 regulation of cation transmembrane transport GO:0051047 positive … ferhat soccer