Cytohesin-1
WebAug 18, 2003 · Cytoplasmic exchange factors for ARFs have been identified; they are called cytohesin-1 , ARNO (cytohesin-2) and GRP-1 (cytohesin-3) . Cytohesin-1 is a 47 … WebMar 11, 2014 · These data suggested that inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR and IGF-I in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro. Therefore, cytohesins or ARNO may be a potential therapy target for some colorectal cancer. …
Cytohesin-1
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WebKolanus W, et al. alphaLbeta2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1 a cytoplasmic regulatory molecule. Cell 86: 233-242, 1996. PubMed: 8706128 ... Jang SI, et al. Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene. J. Biol ... Cytohesin-1 (CYTH1) is a member of the cytohesin family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Memb…
WebFeb 23, 2024 · Initially, CYTH1 was identified in a protein-protein interaction screen and found to interact specifically with the cytoplasmic part of the integrin β2 chain of LFA-1 … WebJun 6, 2000 · Cytohesin-1 comprises an N-terminal coiled-coil domain, which may aid in oligomerization, a central Sec7 domain and a C-terminal module including the pleckstrin homology (PH) domain and a polybasic region. Cytohesin-1 specifically binds to the intracellular domain of the β-2 integrin chain and has been implicated in the functional …
WebThe cytohesin-1–targeting vector was constructed by replacing the ~3.6-kb Xba I fragment containing exons 4 to 7 of cytohesin-1 within the fragment containing exons 4 to 11, … WebCYTIP cytohesin 1 interacting protein [ (human)] Gene ID: 9595, updated on 29-Mar-2024 Summary The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.
WebJun 6, 2000 · Cytohesin-1 comprises an N-terminal coiled-coil domain, which may aid in oligomerization, a central Sec7 domain and a C-terminal module including the pleckstrin …
WebMay 3, 2024 · The cytohesin proteins, consisting of four closely related members (cytohesins-1, -2, -3, and -4), are a subfamily of the Sec7 domain-containing guanine nucleotide exchange factors for ADP... poway unified bell schedulesWebCytohesin-1 is required for Schwann cell migration and that phosphorylation of cytohesin-1 at the Tyr-382 position is important for migration. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. poway unified calendar 2021WebImmunofluorescent analysis of Cytohesin 1, 2 in HeLa Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a Cytohesin 1, 2 monoclonal antibody (Product # MA1-062) at a dilution of 1:100 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated ... poway unified calendarWebOrthologs 1; Homo sapiens (human): CYTH1 (cytohesin 1) HGNC: EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Treefam: Mus musculus (house mouse): Cyth1 (cytohesin 1) Transitive Ortholog Pipeline: Transitive Ortholog Pipeline: Chinchilla lanigera (long-tailed chinchilla): Cyth1 (cytohesin 1) Transitive Ortholog Pipeline: … poway unified board of educationWebApr 14, 2015 · The cytohesins are a class of BFA-resistant small GEFs for ADP-ribosylation factors (ARFs), which regulate cytoskeletal organization, integrin activation, or integrin signaling. The application of SecinH3 in human liver cells showed that insulin receptor complex-associated cytohesins are required for insulin signaling. towamencin youth baseballWebJan 8, 2024 · Cytohesin 1 is a β2 IBP, and particularly it interacts with the leukocyte integrin αLβ2. Cytohesin-1 function as a guanine-nucleotide exchange factor for some GTPases. poway unified employmentWebCytohesin-1 is a guanine nucleotide exchange factor for the GTPase ARF as well a regulator of cell adhesion. When injected into athymic mice, the transformed Rat-3 cell … poway unified enrollment